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Blocking Tumor-Educated MSC Paracrine Activity Halts

Details: This process may involve the education of bone marrow–derived and/or local specialized cells that shape a favorable environment at the metastatic site for …

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› Url: https://clincancerres.aacrjournals.org/content/23/14/3721 Go Now

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A Neoadjuvant Chemotherapy Trial for Early Breast

Details: State and HCO-driven education, community outreach, peer-to-peer counseling, experiential videos, and other media interviewing diverse vaccinated individuals, teaching by primary care clinicians, lay persons, and clergy. Build common ground when facts alone are insufficient. Lack of information on outcomes of vaccine education and public

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› Url: https://clincancerres.aacrjournals.org/content/clincanres/early/2021/07/01/1078-0432.CCR-21-1133.full.pdf Go Now

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Is Conflict of Interest Becoming a Challenge for

Details: Finally, education of researchers on COI is a requirement of the new PHS regulations. Education can be achieved through carefully written institutional policies, guidelines, mandatory training reviews, and educational sessions at national meetings. Disclosure of Potential Conflicts of Interest.

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› Url: https://clincancerres.aacrjournals.org/content/19/15/4034 Go Now

• Get more: Journal of experimental and clinical researchGo Now

MAPK Pathway and TERT Promoter Gene Mutation …

Details: Purpose: Ethnic differences are conspicuous in melanoma. This study is to obtain a comprehensive view of a genomic landscape and a better understanding of the correlations of gene mutation status with clinicopathologic characteristics and disease prognosis in the Asian population. Experimental Design: A total of 2,793 melanoma patient samples were retrospectively collected and …

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› Url: https://clincancerres.aacrjournals.org/content/23/20/6120 Go Now

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A Neoadjuvant Chemotherapy Trial for Early Breast Cancer

Details: To address this problem, vaccine education and public engagement are essential to overcome hesitancy, while equity of distribution is needed to address access. To accomplish these goals, healthcare organizations (HCO) need to not only call out disinformation but also engage the public with vaccine education and find common ground for vaccine

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› Url: https://clincancerres.aacrjournals.org/content/early/2021/07/01/1078-0432.CCR-21-1133 Go Now

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Open-label, Multicenter, Phase II Study of RC48-ADC, a

Details: Purpose: To evaluate the efficacy and safety of RC48-ADC, a novel humanized anti-HER2 antibody conjugated with monomethyl auristatin E, in patients with HER2+ locally advanced or metastatic urothelial carcinoma (mUC) refractory to standard therapies. Patients and Methods: This was a phase II, open-label, multicenter, single-arm study of patients with HER2+ (IHC status 3+ or 2+) locally

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› Url: https://clincancerres.aacrjournals.org/content/27/1/43 Go Now

• Get more: Journal of experimental and clinical cancerGo Now

Keratinocyte Carcinomas: Current Concepts and Future

Details: Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are keratinocyte carcinomas, the most frequently diagnosed cancers in fair-skinned populations. Ultraviolet radiation (UVR) is the main driving carcinogen for these tumors, but immunosuppression, pigmentary factors, and aging are also risk factors. Scientific discoveries have improved the understanding of the …

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› Url: https://clincancerres.aacrjournals.org/content/25/8/2379 Go Now

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New Life for Immunotoxin Cancer Therapy Clinical …

Details: Immunotoxins are targeted anticancer therapeutics that kill cancer cells using a cytotoxic bacterial toxin payload. Their development for use in solid tumor malignancies was delayed due to issues with their immunogenicity and limited therapeutic window. However, new research has rejuvenated the field. Coadministration with a lymphocyte-depleting regimen of pentostatin and cyclophosphamide can

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› Url: https://clincancerres.aacrjournals.org/content/22/5/1055 Go Now

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CD19-specific CAR T Cells that Express a PD-1/CD28

Details: Purpose: CD19-specific chimeric antigen receptor (CAR) T-cell therapy is effective against refractory or relapsed (R/R) B-cell lymphoma, but the efficacy is hindered by the existence of PD-1/PD-L1 pathway. Patients and Methods: Here, we generated a novel anti-CD19 CAR-expressing PD-1/CD28 chimeric switch-receptor (CD19-PD-1/CD28-CAR). We then conducted a phase Ib study to evaluate safety and

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› Url: https://clincancerres.aacrjournals.org/content/27/2/473 Go Now

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Alterations in the Transcriptional Programs of Myeloma

Details: This work was supported by grants from the Ministry of Education (NRF-2017R1D1A1B03032194), the Ministry of Science and ICT (NRF-2016R1A5A1011974, NRF-2017M3A9A7050803, NRF-2017M3C9A6044636, and 2018M3C9A6017315), and the Ministry of Food and Drug Safety (16173MFDS004), Republic of Korea.

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› Url: https://clincancerres.aacrjournals.org/content/26/4/935 Go Now

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Early Use of High-Dose Glucocorticoid for the Management

Details: Experimental Design: In this multicenter retrospective analysis, patients treated with anti–PD-1 monotherapy between 2009 and 2019 and detailed GCC use, data were identified from five independent cohorts, with median follow-up time of 206 weeks. IrAEs were tracked from the initiation of anti–PD-1 until disease progression, initiation of a new therapy, or last follow-up.

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› Url: https://clincancerres.aacrjournals.org/content/early/2021/09/25/1078-0432.CCR-21-1283 Go Now

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Large-scale Analysis of PDGFRA Mutations in Melanomas and

Details: This work was supported by grants from the National Natural Science Foundation of China (81172196, 81102068, and 81272991), Doctoral Fund of Ministry of Education of China (20110001120070 and 20120001110048), the Beijing Nova Program (Z121107002512042), the Program for Beijing Science Topics (Z111107058811101), the Program for Beijing Medical

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› Url: https://clincancerres.aacrjournals.org/content/19/24/6935 Go Now

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Modernizing Clinical Trial Eligibility Criteria

Details: Purpose: Washout periods and concomitant medication exclusions are common in cancer clinical trial protocols. These exclusion criteria are often applied inconsistently and without evidence to justify their use. The authors sought to determine how washout period and concomitant medication allowances can be broadened to speed trial enrollment and improve the generalizability of trial data to a

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› Url: https://clincancerres.aacrjournals.org/content/27/9/2400 Go Now

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Similarities in Risk for COVID-19 and Cancer Disparities

Details: Root cause contributions for the disparity overlap between COVID-19 and cancer. While cancer is a genetic disease that is influenced by tissue microenvironment, COVID-19 is an infectious disease that is enabled by cellular expression of angiotensin-converting enzyme 2 receptors. However, socioeconomic disadvantages, level of education

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AACR Cancer Progress Report 2015 Clinical Cancer Research

Details: For example, major public education and policy initiatives to combat cigarette smoking have been credited with preventing eight million premature deaths from 1964 to 2014 (35) (see Figure 9, p. 35), and policy initiatives that minimize exposure to other cancer risk factors, such as asbestos and pollutants, have also played a role.

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› Url: https://clincancerres.aacrjournals.org/content/21/19_Supplement/S1 Go Now

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Associations between Single Nucleotide Polymorphisms in

Details: Education was used, although it was not significant at a 0.05 level because of the important association of education and socioeconomic status with cancer incidence reported previously . Likewise, Ashkenazi Jewish ancestry was included because it is a well-known risk factor for breast cancer,

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› Url: https://clincancerres.aacrjournals.org/content/15/6/2192 Go Now

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Emerging Treatment Paradigms in Radiation Oncology

Details: Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as

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› Url: https://clincancerres.aacrjournals.org/content/21/15/3393 Go Now

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Hormone Replacement Therapy and Lung Cancer Risk

Details: Results: HRT use was associated with an overall reduced risk of 34% [odds ratio (OR), 0.66; 95% confidence interval (CI), 0.51–0.89] of lung cancer, after adjusting for age, ethnicity, smoking status, education, body mass index, and menopausal status. The use of estrogen replacement therapy alone was associated with a 35% reduction in lung

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› Url: https://clincancerres.aacrjournals.org/content/10/1/113 Go Now

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Germline Mutations in Cancer Susceptibility Genes in a

Details: Purpose: The prevalence of mutations in cancer susceptibility genes such as BRCA1 and BRCA2 and other cancer susceptibility genes and their clinical relevance are largely unknown among a large series of unselected breast cancer patients in the Chinese population. Experimental Design: A total of 8,085 consecutive unselected Chinese breast cancer patients were enrolled. Germline mutations in 46

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› Url: https://clincancerres.aacrjournals.org/content/23/20/6113 Go Now

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Best Practices in Cancer Nanotechnology: Perspective from

Details: In general, the real use of nanomedicine as an essential part of personalized medicine will also require the development of multiple regulatory guidelines and appropriate training and education . The creation of an “industrial culture” of making nanomedicines, including their standardized testing and characterization, is another challenge.

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› Url: https://clincancerres.aacrjournals.org/content/18/12/3229 Go Now

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A Neoadjuvant Chemotherapy Trial for Early Breast Cancer

Details: While COVID-19 vaccine distribution has addressed vulnerabilities related to age and comorbidities, there is a need to ensure vaccination of patients with cancer receiving experimental and routine treatment, where interruption of treatment by infection is likely to result in inferior outcomes. Among patients with cancer, those undergoing neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy

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› Url: https://clincancerres.aacrjournals.org/content/27/16/4486 Go Now

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Role of Host miRNA Hsa-miR-139-3p in HPV-16–Induced

Details: Approved by Institutional Ethics Committee (IEC), Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Results A total of 110 suspected cases of HNC were analyzed for HPV/HPV-16 infection using PCR (Supplementary Information S1) and were grouped into HPV-negative HNC ( n = 40), Control (HPV-negative, n = 40

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› Url: https://clincancerres.aacrjournals.org/content/23/14/3884 Go Now

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Impact of Broadening Trial Eligibility Criteria for

Details: Purpose: Cancer clinical trials often accrue slowly or miss enrollment targets. Strict eligibility criteria are a major reason. Restrictive criteria also limit opportunities for patient participation while compromising external validity of trial results. We examined the impact of broadening select eligibility criteria on characteristics and number of patients eligible for trials, using

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› Url: https://clincancerres.aacrjournals.org/content/27/9/2430 Go Now

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Harnessing the Power of Patient-Reported Outcomes in

Details: Patient-reported outcomes (PRO) represent an increasingly important mechanism for incorporating patients' experiences and perspectives into their care to enhance cancer care delivery and outcomes. In this article, we discuss the importance of integrating PROs into both the clinical and research settings in oncology and highlight potential challenges.

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› Url: https://clincancerres.aacrjournals.org/content/24/8/1777 Go Now

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Clinical Significance of EpCAM mRNA-Positive Circulating

Details: Translational Relevance. Circulating tumor cells (CTC) expressing epithelial cell adhesion molecule (EpCAM) can be detected in patients with HCC and is an independent prognostic factor of time to recurrence (TTR) in these patients.However, detection of CTCs remained costly via CellSearch system, and clinical significance of these CTCs remained unclear in patients with unresectable HCC.

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› Url: https://clincancerres.aacrjournals.org/content/20/18/4794 Go Now

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Regional Brain Activation during Verbal Declarative Memory

Details: Materials and Methods Participants. Fourteen women (mean age, 55.1 ± 8.0 y; range, 43-65) with metastatic (n = 8) or locally advanced (n= 6) breast cancer and 14 age and education-matched healthy female controls (mean age, 54.2 ± 8.0 y; range, 40-65; P = 0.78; mean education rank, 5 ± 2; P = 0.83) participated in this study.Education data were gathered using the following ranking system: 1

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› Url: https://clincancerres.aacrjournals.org/content/15/21/6665 Go Now

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Serial Circulating Tumor DNA in Predicting and Monitoring

Details: Purpose: We investigated the value of circulating tumor DNA (ctDNA) in predicting tumor response to neoadjuvant chemoradiotherapy (nCRT), monitoring tumor burden, and prognosing survival in patients with locally advanced rectal cancer (LARC). Experimental Design: This prospective multicenter trial recruited 106 patients with LARC for treatment with nCRT followed by surgery.

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› Url: https://clincancerres.aacrjournals.org/content/27/1/301 Go Now

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Radiomics of Multiparametric MRI for Pretreatment

Details: Purpose: We evaluated the performance of the newly proposed radiomics of multiparametric MRI (RMM), developed and validated based on a multicenter dataset adopting a radiomic strategy, for pretreatment prediction of pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer. Experimental Design: A total of 586 potentially eligible patients were retrospectively

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› Url: https://clincancerres.aacrjournals.org/content/25/12/3538 Go Now

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NY-ESO-1 Protein Formulated in ISCOMATRIX Adjuvant Is a

Details: NY-ESO-1 is a 180 amino-acid human tumor antigen expressed by many different tumor types and belongs to the family of “cancer-testis” antigens. In humans, NY-ESO-1 is one of the most immunogenic tumor antigens and NY-ESO-1 peptides have been shown to induce NY-ESO-1-specific CD8+ CTLs capable of altering the natural course of NY-ESO-1-expressing tumors in cancer patients.

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› Url: https://clincancerres.aacrjournals.org/content/10/8/2879 Go Now

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Abstract S02-04: Drive By Flu-FIT: A novel way to mitigate

Details: The results of colonoscopy are pending. Conclusions This research shows that a socially-distanced Drive By Flu-FIT program is feasible, acceptable and effective in engaging the community in CRC education and screening during the COVID-19 pandemic.

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› Url: https://clincancerres.aacrjournals.org/content/27/6_Supplement/S02-04 Go Now

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Development and Validation of a Combined Hypoxia and

Details: Introduction. Head and neck cancer (HNC) is the sixth most common cancer worldwide, with an annual incidence of around 600,000 cases. It has a poor outcome with a 5-year mortality rate of around 50% ().The main risk factors include smoking, alcohol, and infection with high-risk human papillomaviruses (HPV), the latter conferring considerably better survival outcomes than the former two ().

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› Url: https://clincancerres.aacrjournals.org/content/25/17/5315 Go Now

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AACR-FDA-NCI Cancer Biomarkers Collaborative Consensus

Details: Stakeholder education and communication are areas of ongoing need in the dynamic biomarker field, and are particular strengths of the AACR. The CBC will leverage AACR venues, including its numerous scholarly publications, the CR advocacy magazine, its Annual Meeting and many other international meetings, educational workshops, and website

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› Url: https://clincancerres.aacrjournals.org/content/16/13/3299 Go Now

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Modernizing Clinical Trial Eligibility Criteria

Details: Purpose: Performance status (PS) is one of the most common eligibility criteria. Many trials are limited to patients with high-functioning PS, resulting in important differences between trial participants and patient populations with the disease. In addition, existing PS measures are subjective and susceptible to investigator bias. Experimental Design: A multidisciplinary working group of the

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› Url: https://clincancerres.aacrjournals.org/content/27/9/2424 Go Now

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Hypoxia and Metastasis Clinical Cancer Research

Details: Hypoxia and Metastasis. In this issue of Clinical Cancer Research, Rofstad et al. ( 1) report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D-12 and R-18 human melanoma xenografts on the development of metastatic disease. That tumors may contain different subpopulations of hypoxic

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› Url: https://clincancerres.aacrjournals.org/content/13/7/1947 Go Now

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Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows

Details: Purpose: To investigate the safety, clinical efficacy, virus pharmacokinetics, shedding, and immune response after administration of an oncolytic parvovirus (H-1PV, ParvOryx) to patients with metastatic pancreatic ductal adenocarcinoma (PDAC) refractory to first-line therapy. Patients and Methods: This is a noncontrolled, single-arm, open-label, dose-escalating, single-center clinical trial.

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› Url: https://clincancerres.aacrjournals.org/content/27/20/5546 Go Now

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Heterogeneous Mechanisms of Primary and Acquired

Details: Purpose: To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or rociletinib (CO-1686). Experimental Design: We analyzed tumor biopsies from seven patients obtained before, during, and/or after treatment with AZD9291 or rociletinib (CO-1686).

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› Url: https://clincancerres.aacrjournals.org/content/22/19/4837 Go Now

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Modernizing Clinical Trial Eligibility Criteria

Details: Purpose: In clinical research, eligibility criteria promote patient safety and optimize the evidence generated from clinical trials. However, overly stringent eligibility criteria, including laboratory requirements, may limit enrollment, resulting in delayed trial completion and potentially limiting applicability of trial results to a general practice population.

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› Url: https://clincancerres.aacrjournals.org/content/27/9/2416 Go Now

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Development and Validation of Machine Learning–based Model

Details: Purpose: Nodule evaluation is challenging and critical to diagnose multiple pulmonary nodules (MPNs). We aimed to develop and validate a machine learning–based model to estimate the malignant probability of MPNs to guide decision-making. Experimental Design: A boosted ensemble algorithm (XGBoost) was used to predict malignancy using the clinicoradiologic variables of 1,739 nodules from 520

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› Url: https://clincancerres.aacrjournals.org/content/27/8/2255 Go Now

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Mechanistic Exploration of Cancer Stem Cell Marker Voltage

Details: The 1B50-1 antibody and isotype IgG were supplied by Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute (Beijing, China). 1B50-1 was directly labeled with PE-Cy5 or fluorescein using the respective Lightning conjugation kits following the

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› Url: https://clincancerres.aacrjournals.org/content/24/9/2148 Go Now

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Genetic Modulation of Neurocognitive Function in Glioma

Details: Generally, patients with less education, female gender, older age, temporal or parietal lobe tumor, left hemisphere tumor, higher grade histology, and carriers of more at-risk alleles tended to have worse NCF. Specifically, education and at-risk SNPs effects were seen …

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› Url: https://clincancerres.aacrjournals.org/content/21/14/3340 Go Now

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Physical Activity and Cancer Outcomes: A Precision

Details: There is increasing interest in applying a precision medicine approach to understanding exercise as a potential treatment for cancer. We aimed to inform this new approach by appraising epidemiologic literature relating postdiagnosis physical activity to cancer outcomes overall and by molecular/genetic subgroups. Across 26 studies of breast, colorectal, and prostate cancer patients, a 37%

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› Url: https://clincancerres.aacrjournals.org/content/22/19/4766 Go Now

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Thyroid Cancer: Risk-Stratified Management and

Details: Thyroid cancer is the most common endocrine malignancy. Differentiated thyroid cancer (DTC) with the two subtypes, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC), is the most frequent subtype of thyroid cancer; more rare subtypes are medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC). The incidence of DTC has increased rapidly in recent years due to …

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› Url: https://clincancerres.aacrjournals.org/content/22/20/5012 Go Now

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SIRT6 Overexpression Potentiates Apoptosis Evasion in

Details: Purpose: To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC). Experimental Design: The expression of SIRT6 in 60 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry. The expression of SIRT6 in 101 paired frozen HCC tissues and adjacent nontumoral liver tissues was analyzed by Western blotting analysis and qPCR.

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Evaluating a New Marker’s Predictive Contribution

Details: Univariable Analysis. The next analysis often provided is a plot of Kaplan-Meier curves for the new marker. An example of this can be seen in Fig. 1 ⇓, where curves illustrate survival for high and low expression levels of a new marker.These curves are indeed informative regarding insight into the time to failure for groups of patients.

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Prognostic Value of Deep Learning PET/CT-Based Radiomics

Details: Purpose: We aimed to evaluate the value of deep learning on positron emission tomography with computed tomography (PET/CT)–based radiomics for individual induction chemotherapy (IC) in advanced nasopharyngeal carcinoma (NPC). Experimental Design: We constructed radiomics signatures and nomogram for predicting disease-free survival (DFS) based on the extracted features from PET and …

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FGFR2 Gene Amplification in Gastric Cancer Predicts

Details: Purpose: FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic potential of AZD4547, a potent and selective ATP-competitive receptor tyrosine kinase inhibitor of fibroblast growth factor receptor (FGFR)1–3, in patients with FGFR2 -amplified gastric cancer.

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› Url: https://clincancerres.aacrjournals.org/content/19/9/2572 Go Now

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Overexpression and Amplification of Aurora-A in

Details: Purpose: Aurora-A/STK15/BTAK, a centrosome-associated serine/threonine kinase, has been shown to induce chromosomal instability, leading to aneuploidy and cell transformation. The purpose of this study was to investigate the expression and amplification of Aurora-A in hepatocellular carcinoma (HCC). Experimental Design: Aurora-A mRNA levels were measured in 224 HCCs and 199 paired …

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